Available January 2020

Are you looking for a safe and effective anti-inflammatory alternative for your Equine partner?

Studies show 60% of all equine lameness are related to osteoarthritis, and can affect any horse at any age. Osteoarthritis (OA) is a disease of joints with multifactorial causes resulting in the progressive degradation and destruction of articular cartilage: the very thin layer of highly specialized connective tissue lining the ends of the long bones where they join. In young horses, OA is predominantly trauma-related. Among equine joint diseases with the greatest impact and clinical relevance in orthopedics, OA remains the most devastating. The condition is often associated with poor performance, early retirement, and a significant financial burden for owners of affected animals.

Equine OA affects all Types of Horses

Equine OA is a painful and debilitating disease that can develop rapidly (when secondary to trauma) or slowly (months to years), depending on the cause. It is common in all horse types; however, it tends to affect joints with a larger and smaller range of movement in sport horses and leisure horses, respectively. Trauma can damage joints in a number of ways, but can be categorized into two major pathways: abnormal forces on normal cartilage or normal forces on abnormal (diseased) cartilage. This is especially true for performance horses where repeated cycles of athletic trauma exist.

OA Development Remains Unclear

In recent years, researchers have described equine OA not as a single disease, but as the final stage of destruction of the articular cartilage, with early stages being triggered and perpetuated by many random factors. However, the exact sequence of events leading to OA development remains unclear, and the temporal relationship between subchondral bone (located just under the cartilage surface within a joint) damage, chronic synovial membrane (the joint capsule’s inner lining, which secretes lubricating synovial fluid) inflammation, and cartilage damage remains unknown.

  • Limping or lameness
  • Joint swelling
  • Decreased turnout activity
  • Stiffness or decreased movement of joints

Alpha2EQ is an exciting advancement in orthopedic science resulting from years of research. For most athletes suffering with pain, their joint space contains more destructive enzymes than their body can handle, resulting in inflammation, and degradation of the cartilage and eventually the bone. Located in the blood is Alpha-2-Macroglobulin (α2M), a molecule that is found to prevent the breakdown of cartilage while also protecting the joint. While α2M is naturally occurring, it is unable to enter the joint space in high enough quantities due to its large size, complex structure, and the avascular design of the joint. As a result, it is necessary to inject additional concentrated α2M into the affected area to help restore balance and experience pain relief.

How does Alpha2EQ work?

Alpha-2-Macroglobulin is a powerful inhibitor of cartilage catabolic factors and slows the progression of OA by preventing cartilage breakdown and loss. Alpha-2-Macroglobulin has two binding sites, which capture proteases like a Venus fly- trap. Once captured, the bound α2M and proteases are eliminated from the joint space through the body’s natural processes.

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How does Alpha2EQ concentrate A2M?

A simple blood draw is taken from the athlete then processed through the Alpha2EQ patented and proprietary filtration method that concentrates α2M up to 6X. Once the process is complete, the α2M rich injectate is drawn off into syringes for administering into the injury site. An injection of concentrated α2M, derived from the athlete’s own blood, can provide the necessary amount of α2M to bind and remove the destructive proteases that are known to cause inflammation.

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A safe, affordable and effective anti-inflammatory alternative. Demand the best. Demand Alpha2EQ.

Faster Recovery and Lasting Results

  • Our patented method creates a more concentrated serum for more effective relief
  • Simple, short and minimally-invasive process
  • Proven success in decreasing inflammation, relieving pain and modulating cartilage degeneration
  • Attending Veterinarians can treat via multiple injections, freezing the concentrated α2M for future applications
  • No harmful side effects (ie. steroids)

Get In Touch

Email: info@astariaglobal.com

Phone: (800) 287-8156